Linear polyubiquitin chains
نویسندگان
چکیده
منابع مشابه
A ubiquitin ligase complex assembles linear polyubiquitin chains.
The ubiquitin system plays important roles in the regulation of numerous cellular processes by conjugating ubiquitin to target proteins. In most cases, conjugation of polyubiquitin to target proteins regulates their function. In the polyubiquitin chains reported to date, ubiquitin monomers are linked via isopeptide bonds between an internal Lys and a C-terminal Gly. Here, we report that a prote...
متن کاملNew conformations of linear polyubiquitin chains from crystallographic and solution-scattering studies expand the conformational space of polyubiquitin.
The conformational flexibility of linkage-specific polyubiquitin chains enables ubiquitylated proteins and their receptors to be involved in a variety of cellular processes. Linear or Met1-linked polyubiquitin chains, associated with nondegradational cellular signalling pathways, have been known to adopt multiple conformations from compact to extended conformations. However, the extent of such ...
متن کاملDistinct consequences of posttranslational modification by linear versus K63-linked polyubiquitin chains.
Polyubiquitin chains mediate a variety of biological processes, ranging from proteasomal targeting to inflammatory signaling and DNA repair. Their functional diversity is in part due to their ability to adopt distinct conformations, depending on how the ubiquitin moieties within the chain are linked. We have used the eukaryotic replication clamp PCNA, a natural target of lysine (K)63-linked pol...
متن کاملMolecular discrimination of structurally equivalent Lys 63-linked and linear polyubiquitin chains.
At least eight types of ubiquitin chain exist, and individual linkages affect distinct cellular processes. The only distinguishing feature of differently linked ubiquitin chains is their structure, as polymers of the same unit are chemically identical. Here, we have crystallized Lys 63-linked and linear ubiquitin dimers, revealing that both adopt equivalent open conformations, forming no contac...
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Cells respond rapidly to changes in their internal and external environments, often by using post-translational protein modifications to transmit signals from the cell surface or internal sites to the nucleus. These signaling pathways allow cells to respond to growth signals, tolerate stresses or trigger programmed cell death. In general, signaling pathway activation is transient, with feedback...
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ژورنال
عنوان ژورنال: Cell Cycle
سال: 2011
ISSN: 1538-4101,1551-4005
DOI: 10.4161/cc.10.18.17437